Doença hepática aloimune gestacional: um relato de caso.

Abstract

Acute neonatal liver failure in the first 30 days of life is a rare and very severe disease with a high mortality rate, being clinically and etiologically different from acute liver failure in older children and adults. The most common cause is fetal alloimmune hepatitis, formerly called neonatal hemochromatosis, among other causes are viral infections, metabolic disorders and hemophagocytic lymphohistiocytosis. The objective of this work is to report the clinical case of a female newborn, who was hospitalized in the High Risk Nursery of the Fernandes Figueira National Institute of Health for Women, Children and Adolescents (IFF∕FIOCRUZ) with the diagnosis of Acute liver failure due to gestational alloimmune liver disease. To discuss the subject, a bibliographic review of the topic was carried out, selected through the PUB MED and CLINICAL KEYS data search system, with the following keywords: gestational alloimmune liver disease; neonatal acute liver failure; neonatal cholestasis.