Terapêutica medicamentosa no domínio agressivo do espectro da psicopatia: revisão de literatura.

Abstract

Psychopathy is the most severe spectrum of antisocial personality disorder, which has clear genetic inheritance. It possesses an impulsive and biologically determined nature, which may or may not be expressed, including resulting from the influence of epigenetics for its occurrence. This medico-legal construct, with a marked emergence in early adulthood, after synaptic pruning, is directly related to the high rates of criminal recidivism as a result of difficult social rehabilitation due to failure to learn through experience, hence the importance of constant updates on this personality disorder. Objective: to synthesize the literature on the main psychotropic drugs currently used to reduce or prevent impulsive aggressiveness, one of the most problematic dimensions of psychopathic disorder. Methodology: This is a narrative review of the literature with a descriptive and qualitative nature, fundamentally exploratory, based on articles, in English and Portuguese, published in the PubMed, Scielo, LILACS and Google academic databases. The survey considers articles published in the last five years. Result/discussion: psychopathy is a forensic construct that exhibits potential for drug treatment, especially in relation to the area of aggressive behavior, however, it needs to be better defined and classified so that there is an adequate therapeutic procedure. Conclusion: more research is needed in the fields of molecular biology, genetics, imaging and hormone therapies in order to allow advances in the diagnosis and treatment of this syndrome.