O uso da quetiapina no transtorno de personalidade com instabilidade emocional: uma revisão de literatura.

Abstract

Emotionally unstable personality disorder (EUPD) is a nosological entity that was first described at the late of the 19th century, but which only gained notoriety and attracted the attention of scientific research in the last century. OBJECTIVE: This study aimed to conduct a literature review about on the medication approach with the use of quetiapine in patients with EUPD, providing data such as tolerability and efficacy of this psychotropic in this context. METHODOLOGY: An active search was carried out in the main scientific databases, in order to compile studies on the proposed topic, prioritizing publications from the last five years and adding some relevant works in the area. RESULTS AND DISCUSSION: The EUPD presents marked personality characteristics, such as affective instability and instability in interpersonal relationships, impulsivity, recurrent thoughts of death and self-mutilation, among others, which makes this morbidity preponderant in medical practice, as these individuals become vulnerable to suicide and to other psychiatric disorders. Some studies have brought quetiapine as an interesting therapeutic alternative for these patients, especially at a dosage of 150 miligrams per day for 8 weeks. CONCLUSION: Although there are promising results regarding the benefits of the use of quetiapine for patients with EUPD, there is still no approval by competent organizations, in any country, of drugs indicated for this user profile, so their use should be judicious, according to symptoms dysfunctional and strict necessity, requiring further studies to support drug therapy in these cases.