Aspectos radiológicos dos macroadenomas hipofisários clinicamente não funcionantes invasivos

Abstract

The Non Functioning Adenomas (NFPA) are pituitary tumors that don’t secrete hormones or those with hormone production that is not sufficient to cause clinically identifiable symptoms. ACNF correspond to about 28% of pituitary adenomas; on the other hand, pituitary adenomas constitute only 10% of intracranial neoplasms. Macroadenomas can compress the optic chiasm and cause visual deficits, as well as lead to hyperprolactinemia and hypopituitarism. Transsphenoidal surgery, added to histopathological and immunohistochemical analysis, is the gold standard diagnostic and therapeutic procedure for macroadenomas. However, the recurrence rate of these lesions is 30 to 50% between 5-10 years. In this context, the Modified Knosp Score becomes an important tool, as it is based on the radiological characteristics of the lesion to predict the chances of total surgical resection. The present work consists of a bibliographic review of Clinically Non-Functioning Invasive Pituitary Macroadenomas, with the objective of demonstrating the radiological aspects of these tumors and the importance of the Modified Knosp Classification not only in the therapeutic planning but also in the alignment of expectations with the patient regarding the limitations and complications of surgical treatment.